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When compared with placebo or other therapies, GLP-1 agonists were associated with an increased risk of biliary disease [23]: Overall biliary disease: RR 1.37(95% CI 1.231.52) Cholelithiasis: RR 1.27 (95% CI 1.101.47) Cholecystitis: RR 1.36 (95% CI 1.141.62) Mechanisms: Reduced gallbladder motility Rapid weight loss increased cholesterol saturation and gallstone formation

[DOI] [PMC free article] [PubMed] [Google Scholar] 142.Martins C., Gower B.A., Hill J.O., Hunter G.R

"Safety Alerts for Human Medical Products Chantix (varenicline) and Zyban (bupropion)"

At this time, GLP-1/GIP medications should not be represented as disease-modifying therapy for autoimmune disorders

This condition is called Sarcopenia (muscle poverty)